Clinical Efficacy of Sublingual Specific Immunotherapy in Children with Allergic Rhinitis and its Impact on their Inflammatory Factors and Immune Function
نویسندگان
چکیده
The main objective of this study is to analyze the effects sublingual specific immunotherapy and conventional drug therapy on inflammatory factors immune function in children with allergic rhinitis. research subjects were divided into three groups, group A received administration dust mite drops, B routine treatment such as passive intervention topical hormones, antihistamines nasal irrigation C drops basis drop therapy, treatments systemic use corticosteroids, anti-leukotriene’s are combined. Comparison was done among different sets indicators. After treatment, rhinitis symptom score, visual analog scale score factor index levels groups calculated. lower than A. Adverse reactions lowest highest C. whole blood cluster differentiation 4+, 4+/cluster 8+ cells serum immunoglobulin E A, B. Sublingual effective safe for
منابع مشابه
Sublingual Immunotherapy in Children with Allergic Rhinitis
The prevalence of allergic disease has been increasing over time and now represents a global health problem. For example, allergic disease in the UK affects up to 40% of children with allergic rhinitis accounting for a significant component of the allergic burden. There is also specific evidence for increasing prevalence of allergic rhinitis in the UK paediatric population, particularly among y...
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Allergic rhinitis (AR) is a globally increasing health problem affecting the quality of life. Specific immunotherapy is an available causal treatment changing the basic allergic mechanisms of the disease. Over one hundred years, subcutaneous immunotherapy (SCIT) was developed and proved its efficacy but many adverse effects were recorded including anaphylaxis. In 1986, sublingual immunotherapy ...
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Zorica ŽIVKOVIĆ Kneginje Zorke 9, 11000 Belgrade Serbia [email protected] SUMMARY In 1993 the European Academy of Allergy and Clinical Immunology was the first official organization to recognize that sublingual administration could be “promising route” for allergic desensitization. A few years later, the World Health Organization recommended this therapy as “a viable alternative to the i...
متن کاملSuppression of TIM-1 predicates clinical efficacy of sublingual immunotherapy for allergic rhinitis in children.
OBJECTIVE To evaluate the clinical efficacy of sublingual immunotherapy (SLIT) with house-dust mite (HDM) extract and to examine the change of biomarkers (TIM-1, IL-5 and IL-10) after 6-month SLIT in children with allergic rhinitis (AR). METHODS One hundred and sixteen HDM-sensitized children with persistent AR were enrolled to assess the clinical efficacy of SLIT by determining the individua...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2023
ISSN: ['0250-474X', '1998-3743']
DOI: https://doi.org/10.36468/pharmaceutical-sciences.spl.669